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Suggested Mechanisms of Al-Hijamah as a Percutaneous Excretory Procedure That May Clear Serum and Interstitial Fluids of Hepatitis Patients from Disease-Causing Substances Causative pathological substances (CPS) in viral hepatitis (both HBV and HCV infections) include the virus particle itself (B or C especially during stage of viremia), viral antigens (eg, HBs Ag and HBe Ag), viral nucleic acid (DNA in hepatitis B and RNA in hepatitis C), inflammatory cytokines, free radicals and the resultant antigen-antibody complexes (in hepatitis B) (Figure 3)