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ACT-AD (phase 2) missed its primary endpoint, SHAPE (phase 2) was terminated, and LIFT-AD (phase 2/3, 549 dosed and 287 in the primary analysis, topline September 2024) missed its primary endpoint and all key secondary endpoints for cognition and function
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Soon, there were generalized strong irregularity diameter blood vessels with severe atrophy of the optic disc and extremely poor presentation of the choroidal blood vessels