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B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease - PMC

Long-term metformin use clearly associates with increased b12 deficiency rates

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Challenges such as safety, dosage optimization, and long-term effects need to be thoroughly addressed before considering 5-Amino-1MQ as a viable anti-aging intervention for humans

Some of the biggest risk factors for B12 deficiency are vegetarian/vegan diets