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This N-terminal fragment retains full biological activity at the pituitary GHRH receptor (GHRHR), a G-protein coupled receptor that activates adenylyl cyclase, raises intracellular cAMP, and triggers pulsatile GH secretion from somatotroph cells

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Application in Studies of NNMT‑Related Energy Metabolism Mechanisms Given its core advantage of selectively inhibiting NNMT and regulating NAD+ synthesis, 5-amino-1-methylquinolinium injection serves as a foundational tool for investigating the role of NNMT in energy metabolism and dissecting the molecular pathways of metabolic disorders