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Seminal studies by Finkel’s team and by Rhee’s team showed that ligand binding by the PDGF receptor, EGF receptor, T cell receptor, and other transmembrane receptors was associated with, in addition to auto-phosphorylation of tyrosyl domains on the cytosolic portion of the receptor, activation of a membrane-associated NADPH-oxidase (NOX) complex [153–160]

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