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It should be noted that the studies performed using edited sequences (Emir et al., 2011, Hupfeld et al., 2021, Lally et al., 2016, Suri et al., 2017) used long TEs, and therefore, possible age-related differential changes in T2 relaxation time of GSH relative to the water or creatine quantitation reference could have confounded estimations of age-related concentration differences