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Here, we examine studies that have combined molecular and behavioural approaches in rodents to elucidate the molecular mechanisms that keep the social intake of alcohol in check, which we term 'stop pathways', and the neuroadaptations that underlie the transition from moderate to uncontrolled, excessive alcohol intake, which we term 'go pathways'

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These possible unwanted effects include pathologic angiogenesis, toxic metabolite formation, and overproduction of nitric oxide [23]